immunology

We have over 25 years of experience in this segment
As a scientific discipline immunology explains physiological defense mechanisms against foreign objects, like viruses and bacteria. In contrast to that, an immunoassay is a laboratory diagnostic test that utilizes an immunological reaction for detection purpose. It measures an analyte in blood samples or other body fluids on the principle of the formation of antibody-antigen complexes where the analyte is one of the two binding partners. Each assay is configured individually and the analyte is detected either in a qualitative (positive or negative) or quantitative (concentration measurement) manner.
The analyte can be some natural part of the body (e.g. hormones), may be produced by the body under specific conditions (e.g. cancer antigen), or of those that normally do not occur (e.g. a Hepatitis B antigen). Immunoassays generally include a specific method (e.g. enzymatic or fluorescent labels) to generate an amplified signal that depends on the present amount of analyte. For many assays, all steps to detect the analyte can be carried out manually, but also semi-automated solutions or fully-automated analyzers are available.
Immunoassays generally use a method that produces an amplified signal that can then be visualized by using an analyzer or another detection method.

BIT’s track record

From compact ELISA instruments to high throughput chemiluminescent instruments
BIT has worked with its global clients to automate immunodiagnostics from compact tabletop physician’s office laboratory (POL) devices to large floor-standing chemiluminescent systems. We have expertise with colorimetric, luminescent and fluorescent detection as well as managing microparticles in the assay.

We have worked on a variety of instrument solutions from POL to the core lab.

key features

What makes our devices special
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ELISA

  1. Antigens from the sample are attached to a surface. Then, a further specific antibody is applied over the surface so it can bind to the antigen.
  2. This antibody is linked to an enzyme, and, in the final step, a substance containing the enzyme’s substrate is added.
  3. The subsequent reaction produces a detectable signal, most commonly a color change in the substrate.
BIT has extensive expertise in automating assays with colorimetric, turbidimetric and nephelometric detection, i.e. those that use visible light. Our standard colorimetric detection module is well-suited to ELISA assays.
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Chemiluminescent immunoassay

  1. Chemiluminescence is the emission of light (luminescence), as the result of a chemical reaction.
  2. This phenomenon, often combined with magnetic microparticles, is used to perform and automate-high performance immunoassays, becoming perhaps the leading modern technique of automated immunoassays in today’s core laboratory.
BIT has years of expertise in automation chemiluminescent immunoassays including related techniques and technologies such as application of PMTs, magnetic bead management, assay mixing and elimination of carryover.

immunology devices

Portfolio Excerpts
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DRG Hybrid XL
  • Unique combination of clinical chemistry and ELISA in one instrument
  • Competitive compact benchtop instrument
  • BIT Germany and USA, development and manufacturing
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Orgentec Alegria
  • Random access analyzer, based on SMC® (Sensotronic Memorized Calibration) technology
  • Autoimmune diagnostics and infectious serology
  • BIT Germany manufacturing and after-sales services
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Siemens BEP III
  • Runs ELISA tests fully automated
  • Targeted for for specialty infectious disease testing, including retrovirus (HIV), hepatitis, bacteria, fungi, parasites, worms and the complete range for ToRCH
  • BIT Germany manufacturing and after-sales services
Are you working on a new immunology diagnostic device? Let’s discuss how to help you develop it faster, accelerate the regulatory process and increase your margin.
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Jari Palander
Executive Vice President
Global Business Development
San Francisco, CA
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David Stelter
Vice President
Business Development
San Diego, CA
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Joe Ryan
Vice President
Business Development
Columbus, OH
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Eric Jolain
CEO
BIT Group France
Hematology Expert